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5 Cardinals who must step up for Louisville after Mikel Brown Jr.'s injury update

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The Cardinals will have to play their best basketball to beat one of the best teams in the country.

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Louisville basketball is about to come face-to-face with its biggest opponent of the year. The Cardinals are set to take on the Duke Blue Devils on Tuesday in their third conference game of the season. Louisville has not had an ideal start to its ACC schedule, as it is 1-1, coming off a loss to Stanford.

The Cardinals are hoping to avoid dropping their second game in a row, but it will take everything they have to defeat the No.